APRILE Silvio
Research Activity
Attività di ricerca
The current research activity is primarily focused on ADME-PK studies in different drug discovery and lead optimization projects for new classes of biologically active compounds (inhibitors of the enzyme indoleamine 2,3-dioxygenase - IDO, PROTACs, isocyanides with antibacterial activity), in particular in determining their metabolic stability and metabolic profiling through in vitro incubations and analysis by high-resolution HPLC-MS techniques. Enzymatic inhibition studies are also underway, particularly concerning cytochrome P450s as potential therapeutic targets. The second line of research is focused in the development and validation of HPLC analytical methods for stability studies of active ingredients and drug products.
Parole chiave
ADME, PK, drug metabolism, HPLC techniques, drug stability studies