UPO Book

Attività di ricerca

Our research group is focused on the study of tumor-associated myeloid cells and the identification of inflammatory pathways and molecules drivig their pro-tumor reprogramming during neoplastic progression, with the aim of providing novel molecular targets as possible prognostic indicators and therapeutic targets. Our group has recently identified a distinct population of tumor-associated macrophages, expressing high levels of the enzyme heme oxygenase 1 (HO-1), which establishes a pro-metastatic tumor microenvironment favoring immunosuppression and angiogenesis. Further evidence points to carbon monoxide (CO), derived from the HO-1-catalyzed reaction, as an endogenous gaseous transmitter with anti-inflammatory and anti-apoptotic activities. However, a clearer understanding of the mechanisms underlying its biological effects is needed. Thus, the research activity is aimed at clarifying the molecular and cellular mechanisms mediated by CO that drive tumor cell invasiveness and tumor immunity.

Parole chiave

cancer-related inflammation; solid tumors; macrophages; carbon monoxide; immunosuppression 

IRIS