UPO Book

Attività di ricerca

Our research activity is in the field of immunology with a particular interest in myeloid cells and the molecular mechanisms driving their functional plasticity in cancer and immune-mediated diseases. In recent years, our group has focused on malignant pleural mesothelioma (MPM), an aggressive thoracic cancer. Although MPM is highly resistant to conventional therapies, the advent of immune checkpoint blockades (ICBs) has introduced promising new therapeutic opportunities. Building on this advancement and our recent findings, our current projects aim to: 1) identify novel combination immunotherapies to boost anti-tumor immunity using human multicellular spheroid models and murine orthotopic MPM models 2) identify predictive biomarkers of response to ICBs through analysis of tumor tissue and liquid biopsies from MPM patients. 

Parole chiave

macrophage, cancer, mesothelioma, tumor microenvironment, immunotherapy 

IRIS